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CreGAAtine vs. Traditional Creatine: Separating Fact from Fiction

Updated: Nov 9, 2023

Setting the Scene

In the realm of biohacking, the conversation often circles back to CreGAAtine versus traditional Creatine formulations.

As scientific knowledge deepens, so does our understanding of what truly works. Let’s delve into the research and demystify the claims surrounding these supplements.

The Science Behind CreGAAtine

CreGAAtine, a fusion of Creatine and Guanidinoacetic Acid (GAA), stands out for its innovative blend. Studies have revealed that conventional Creatine Monohydrate and Creatine Ethyl Ester don't significantly impact muscle Creatine content (Spillane et al., 2009). In contrast, CreGAAtine, with its unique composition, leads to substantial increases in both muscle and brain Creatine levels (Semeredi et al., 2019), positioning it as a frontrunner in the biohacking community.

Debunking the Myths

Despite marketing assertions, a comprehensive review has underlined that the safety and efficacy profiles of various Creatine forms don't markedly outshine Creatine Monohydrate (Jäger et al., 2011). CreGAAtine, grounded in robust research, dispels these myths, offering biohackers a supplement that lives up to its promises.


1. Spillane, M., Schoch, R., Cooke, M., Harvey, T., Greenwood, M., Kreider, R., & Willoughby, D. S. (2009). The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. Journal of the International Society of Sports Nutrition, 6, 6.

2. Semeredi, S., Stajer, V., Ostojic, J., Vranes, M., & Ostojic, S. M. (2019). Guanidinoacetic acid with creatine compared with creatine alone for tissue creatine content, hyperhomocysteinemia, and exercise performance: A randomized, double-blind superiority trial. Nutrition (Burbank, Los Angeles County, Calif.), 57, 162–166.

3. Jäger, R., Purpura, M., Shao, A. et al. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids 40, 1369–1383 (2011).

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